Season 15 has changed how Diablo 4 players approach endgame builds. Hell's Legacy puts Mythic Runes and Legacy Runewords at the centre of progression, and the difference is easy to feel once your character reaches tougher Tower tiers. A well-planned setup can improve damage, survivability, and even the speed of gearing, especially when you combine the right base item with useful D4 items.

Building the Right Runeword

The Horadric Cube is now the key crafting station for this system. Start with an Ancestral Rare item that has the right slot and type for your build. The Cube removes its existing affixes and leaves a clean white base. That step matters because ordinary items cannot be raised to Mythic quality. Once the base is ready, place the required runes in the correct order. A small mistake can waste valuable materials, so it is worth checking the recipe before you commit.

Choose an Ancestral Rare base with the correct item type.
Use the Horadric Cube to clear its current affixes.
Insert the required Mythic Runes in sequence.
Test the finished Runeword with your main skills and gear.

Why Infinity Leads Damage Builds

Infinity is the standout choice for players focused on raw output. Its Ber, Mal, Ber, Ist recipe suits characters that want faster kills and stronger burst windows. The Mythic version adds Crushing Blow chance, giving heavy attacks more impact against durable targets. Its secondary effect reaches a 163 percent damage multiplier, compared with 125 percent on the standard version. That gap becomes noticeable in long fights, where every burst cycle can decide whether a run succeeds.

Making Vendor Runs More Productive

Damage is only part of the seasonal race. Edge helps players gain more value from the Purveyor of Curiosities by raising the chance of receiving extra items during gear gambling. Spirit adds another layer to that routine, and players have reported double-drop interactions when both Runewords are active. The practical result is simple: more weapons and armour from the same Obol budget. That makes it easier to find useful Ancestral bases without spending every session in combat.

What to Prioritise in Season 15

Most players should secure a suitable Ancestral base before chasing perfect rune combinations. After that, Infinity is the natural target for damage-focused builds, while Edge and Spirit make sense for anyone still filling equipment gaps. Barbarians pushing Tier 150 have shown how strong the damage setup can become when Infinity is paired with Call to Arms and Enigma. At the same time, efficient vendor runs can keep your supply of usable bases moving, so consider adding D4 items cheap to your broader gearing plan when you are preparing for the next upgrade.